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Cell Biology 2382B Complete Course Notes

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Western University
Biology 2382B

Cell Biology Exam ReviewMembranes and Membrane FunctionsMmebrnes are formed from phospholipids bipolarForm into different types of structures when you put them in aq solutionsHydrophobic chains point away from liquidMembranes on cells are made of phospholipid membranes The properties of fatty acid tails can alter the properties of the membrane itselfMore double bondscan change the properties of the membraneDouble bonds decrease the Tmmore fluid the membrane isThe more double bonds lower Tmmore thungs are able to move around in the membrane o Cant be packed as closely togethero POINT Tm decreases with increasing unsaturation and increases with increasing chain length o Longermore solid the membrane is going to be membranes are composed of phospholipid polar head group attached to tail by phosphatePolar head grouplined to the tail by a phosphate group Phosglucerides are phospholipids tails are derived from glycerolSpingolipids can be phospholipids as wellSpingomyelin a spingolipid polar head group is attached to tail by phosphate phospholipid but backbone is derived from sphingosineNot a phospholipid not linked through phosphateGlycolipid bc the head group is derived from sugar o PC PE PI PSphosphoipids phosphoglycerides o SMphospholipid sphingo lipid o GlcCersphingolipid glycolipid NOT A PHOSPHOLIPIDDepending on which kinds of phospholipids can alter properties of the membraneSM is bigger than PC sos we get a thicker membranePC can be stacked evenly togetherDifferent components in the membrane can alter propertiesSterols Hydroxyl point in same direction as Cholesterol can be there and it can do different thingsFluidity closed compartments semipermeable asymmetric o Fluidity can be altered through changes in temp and composition of membrane whether they have double bonds or not o Outer leaflet are labelled fluorescentlyBleach one area of outer leafletno fluoresecence in that spotIf membrane is fluidget recovery of flyoresecent in that bleached around o Graph showsof fluorescent recovery of fluorescence o 50 of p in membrane are able to move around o Extent of recovery is directly properotional to theof molecules in the membrane that are mobileClosed compartments PM enclose different organelles vesicles within the cytosol o Cytosolic face of membrane PM the inner side of the membrane facing cytoplasm vesicle outside of membraneSemipermeable sm hydrophobic uncharged molecules can pass directly through membraneCharged large cant pass directly through membraneMembranes are ALWAYS ASYMMETRIC different types of p are localized within membraneTransmembrane p cytosolic domain is not identical to exoplasmic domainDifferent function on one side of membrane than other o PM carbohydratesglycos7lation is only the side that faces ECMNever glycosylation on cytoplasmic sideIntegral membrane proteinsAsymmetryOnly have glycosylation on extracellular sideTransmembrane domain is composed of hydrophobic aaCytosolic domain and extracellular domains are hydrophilicThey like waterTransmembrane domain is a region of hydrophobic aa
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