Biology 2581B Final: Genetics Lecture Notes (Part 2)
5 Jan 2018
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Laci repressor by displacing the hinge, thereby preventing the helix-turn-helix domain from binding to dna. Trp operon: tryptophan is an amino acid that is biosynthesized by genes in the. This prevents for formation of a 1-2 hairpin loop, allowing the formation of a 3-4 hairpin loop. The 3-4 hairpin loops triggers rna polymerase to prematurely terminate transcription: if there is a lack of tryptophan in the cell, the ribosome will stall at this point. The stall allows enough time for the formation of a 2-3 hairpin loop, which prevents a 3-4 loops from forming. A full transcript will be constructed, with all genes being translated into functional proteins to synthesize tryptophan. K" = concentration of x* at which gene y is at half its maximal expression level (x* when y = b/2) Lower levels of n" represent more linear, less switch-like behavior.
