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Study Guide

Biology 3592A- Final Exam Guide - Comprehensive Notes for the exam ( 45 pages long!)

45 Pages

Course Code
Biology 3592A
Kathleen Hill

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[Biology 3592A] Comprehensive Fall guide including any lecture notes, textbook notes and exam guides.find more resources at Clonal Mosaicism September 14, 2017 Lecture 1 The Rise of de novo Mutations & Mosaicism • Clonal Mosaicism: arises when a postzygotic mutational event is detectable in subpopulations of cells as an alternative genotype while not present in the germline genome  Was undetectable until recent technological advances • DNA Damage: lesion or broken bond  The first thing that happens to DNA; reversible • Mutation: DNA damage that’s been replicated & proliferated; irreversible • Clonal Expansion: proliferation of mutated cells  Drives it to detectable; more easily detected when cells are expanded • Detectable: 1. Genotypically  lots of cells to a single cell with better tech 2. Phenotypically  what you can see • Purifying Selection: detecting mutations as being aberrant; cause loss of mutation  i.e. immune system gets rid of necrosis from mutation  works on the molecular, inter/intracellular, & systemic level find more resources at
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