Biology 3594A Study Guide - Final Guide: Mitochondrial Disease, Primum Non Nocere, General Idea

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Lecture 4 Flashcards
Front (Term)
Back (Definition)
Germline DNA editing is...
- possible
- feasible
- tangible
- warranted (justified and necessary)
- lawful
PGD
Prenatal genetic diagnosis
- A technique that can enable people to avoid passing gene
mutations, and therefore disease predisposition, on to their
children. It involves testing the genes of embryos created through
IVF.
- embryo autonomy is violated (do we think of embryos has having
personhood)
What questions to consider for
germline DNA editing to go to
clinical trials?
- can it happen in an ethically acceptable way?
- what about individual autonomy? is this intrinsically problematic?
- what about direct consent? is the consent process meaningful?
- is a proxy for consent acceptable?
- is it safe?
Two main ideas about germline
DNA editing going to clinical trials
Trust in the science is key
Parents as gatekeepers
Three-parent offspring
3 different parents contribute DNA to offspring
- maternal DNA, paternal DNA, mitochondrial DNA
- remove the egg from the nucleus (ethical debate)
- used to avoid mitochondrial disease in the child
Considerations in an ethical
decision-making process (7)
Justice - lawful
Fidelity - holding to contract
Beneficence - doing good
Non-maleficence - not doing harm
Veracity - maintaining truthfulness
Transparency - accuracy in communication and informed consent
Autonomy - ensuring freedom from external control of influence,
permitting independence
Considerations in an ethical
decision-making process: 2
pertaining to safety
- Beneficence: doing good - Non-maleficence: not doing harm
Modern human identity: the last
20-30 years
Integrating emotions and other dimensions of our nature into our
definition of identity
Modernity and the human
identity
Human that is continuous, rational, has universal rights
Modern human identity: last 50
years
- identity dissolving into different strands
- gender identity, race, sexual identity
- foster diversity and make it part of the general idea of what it
means to be human
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Document Summary

A technique that can enable people to avoid passing gene mutations, and therefore disease predisposition, on to their children. It involves testing the genes of embryos created through. Embryo autonomy is violated (do we think of embryos has having personhood) Considerations in an ethical decision-making process: 2 pertaining to safety. Remove the egg from the nucleus (ethical debate) Used to avoid mitochondrial disease in the child. Transparency - accuracy in communication and informed consent. Autonomy - ensuring freedom from external control of influence, permitting independence. Beneficence: doing good - non-maleficence: not doing harm. Integrating emotions and other dimensions of our nature into our definition of identity. Human that is continuous, rational, has universal rights. Foster diversity and make it part of the general idea of what it means to be human. After ww2 we tried to come up with something we all share. Foster many forms of identity that separate some groups from other groups.

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