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Sept. 29, 2011 Lecture Notes

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Western University
Biology 3594A
Kathleen Hill

Dogs as Model OrganismsGood model system for eye research because they are diurnal domesticated relatively large eye mammalian genome sequence is known large litter size disease is similar to human disease Lifespan is approximately seven times shorter than humans so diseases progress faster A trial that might take 515 years in humans takes 13 in dogs Dog genome is less diverged from the human genome than the mouse genome and dogs have about the same amount of genes as humans do Family history is a major risk factor for disease susceptibility in dogs just as in humans Some cons about research on dogscost animal testing protocols facilities Mice as Model OrganismsSimilar genomic structure to humans in terms of size and number of genes and show extensive conserved gene order Small easy to maintain in the laboratory and compared to most mammals have a short breeding cycle Large litter size and can produce one littler every month which makes them appropriate for genetic analysisCan introduce mutations by irradiation administration of ch
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