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Exam Review Lecture Notes 2

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Department
Biology
Course
Biology 3594A
Professor
Kathleen Hill
Semester
Fall

Description
Sample Exam QuestionsWhat is transient hyper mutabilityIn humans and a variety of other organisms the frequency of multiple mutations is higher than expected consistent with transient hyper mutability The close spacing of multiple mutations is unexpected and not predicted by the mutator phenotype hypothesis Big Blue transgenic mouse system is very useful for detecting these A mutation shower Chronocoordinate multiple mutations spanning many kilobases or spontaneous multiple mutations with unexpectedly high frequency with one mutation shower spanning 3045 kilo bases A mutation phenotypeSimplest form predicts a higher frequency of independent events with multiple randomly spaced mutations transmitted to their progeny as a result of deleterious somatic mutations affected the integrity of genome maintenance The mutator phenotype arising from mutations in genetic stability genes can have diverse manifestations such as point mutations microsatellite instability and loss of heteroz
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