Biology 1001A Study Guide - Midterm Guide: Dna Mismatch Repair, Dna Replication, Exonuclease
Document Summary
They need a 3" hydroxyl on a properly-paired base. Polymerase iii may recognize that and activate an exo-nucleoid activity(not an another enzyme) To remove that miss match base(damage) and restore the proper base. The mismatched is recognized since it forms a distortion in dna structure. Repair enzymes removes a section of a mismatched pair and then removes a section, break covalent bonds in the backbone. Polymerase iii adds on proper bases and ligase seals gap (will remove from the new strand ! recognized by the non methylated old strand) general trends in costs of dna sequencing. The cost of dna sequencing has decreased as a result of technology improving an nding better methods to sequence dna. Less than 1000$ now, 2000 relative distribution of various components of genome sequence (junk vs. essential dna) 2% of the 3 billion of the genome code for anything to do for being a human.