3393A/B- Midterm Exam Guide - Comprehensive Notes for the exam ( 47 pages long!)

• School: Western University
• Department: Chemistry
• Course: Chemistry 3393A/B
• Professor: Felix Lee

Document Summary

Topic k: metabolic studies and chemical & process development. And these multiple-choice questio(cid:374)s o(cid:374) the te(cid:454)tbook"s (cid:449)ebsite (http://global. oup. com/uk/orc/chemistry/patrick5e/): chapter 15: 2 12. Follow its conversion into a different molecule. Isotopes are hard to work with because they are constantly decaying. Acetaminophen: of the carbon that (cid:449)o(cid:374)"t be re(cid:373)o(cid:448)ed or destro(cid:455)ed, (isotope gas to metabolite). Hydrogen is harder to tag because of hydrogen exchange. Tagging needs to be done in a location where there is stability in place. This is to prevent degradation of the radioactive isotope. Once absorbed, the radioactivity is measured from urine (urinalysis), fecal analysis and blood samples. Have an idea of what the metabolite will be so make them in the lab and compare the fragmentation patterns of the known to patterns of metabolites you get. Hplc and identify which peak is which, to quantify them. A bit of the drug will remain unchanged and that will appear as an unchanged peak in the.