Kinesiology 2032A/B Study Guide - Final Guide: Clofibrate, Blind Experiment

• School: Western University
• Department: Kinesiology
• Course: Kinesiology 2032A/B
• Professor: Harry Prapavessis

Document Summary

Efficacy: refers to whether an intervention works in people who received it. (focus on offers and what happens when they receive it) Biologic effects of therapy are addressing explanatory hypotheses. Intent to treat: in randomized control trials not everyone completes the trial: every subject that was randomized according to randomized treatment assignment. Intent to treat analysis over 5 years 20% drug -mortality, placebo. 20. 9% -mortality does(cid:374)"t (cid:373)atter whi(cid:272)h you take no difference . Randomization is of central importance in clinical trials last observation carried forward. Itt analyses try to prevent the randomization groups and address pragmatic hypotheses about the clinical utility of treatment (what are the results going to look like irrespective of who complied or not) Explanatory analyses address interesting hypotheses about the biological effect of treatment are more prone to bias. Itt analyses should be the primary analyses for most clinical trials. Explanatory analyses should carefully consider the effect of compliance.