[3300B] - Final Exam Guide - Comprehensive Notes fot the exam (59 pages long!)

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Immunoglobulin refers to the domain that is present in antibodies and various other proteins. Mhc molecules, and many other proteins contain one or more of this protein domain, and are consequently part of an ig-superfamily. Antibodies are a type of b-cell receptors (brcs) that are generated in an antigen-specific manner as part of the adaptive immune response. They consist of four polypeptide chains (2 light chains and 2 heavy chains) that are linked to each other by disulfide bonds. Each chain contains an ig domain, and is divided into a variable region and a constant region. Variable region: interacts with antigens; the polypeptide chain can be made up of different amino acid sequences, which leads to the diversity that is present across all antibodies. Constant region: binds to the cell membrane and allows for recognition by fc receptors; the polypeptide chain remains the same, even across different individuals, and the sequence determines the isotype (igm, igg, etc. )

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