Immune Study Notes Lecture 2
Describe the epithelial barrier.
Epithelial has tight junctions that don’t allow anything through. Within the
epithelium in the lungs, goblet cells secrete secretory vesicles that secrete mucous
to the luminal space. Mucous collects dust and the cilia move it out of the airway. In
the gut, there are invaginations with anti pathogen proteins and nutrients can also
get across. Microvilli are the main component here. Goblet cells also secret emucuos
in the gut. In the skin epithelium there are cells that secrete oils to the skin – also
cells differentiate as you move up; lots of keratin (dead cells).
1. What are the chemical defenses of the epithelium?
Lysozymes – break the bacterial cell wall; work best against gram (+) bacteria
sPLA2 – pokes holes in the lipid membrane, cleaves the phospolipid at carbon 2 to
produce lyso phospholipid and a fatty acid – membrane becomes leaky
Defensins and Cathelicidins – AMPH – oligomyze and form a pore
C-type lectins – bind to unique carbohydrates and break the membrane
2. What receptors are involved in detection of self?
Sialyic Acid, M