Microbiology and Immunology 3300B Study Guide - Final Guide: Respiratory Burst, Lipid Bilayer, Phospholipid
29 Mar 2013
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Document Summary
Epithelial has tight junctions that don"t allow anything through. Within the epithelium in the lungs, goblet cells secrete secretory vesicles that secrete mucous to the luminal space. Mucous collects dust and the cilia move it out of the airway. In the gut, there are invaginations with anti pathogen proteins and nutrients can also get across. Goblet cells also secret emucuos in the gut. Lysozymes break the bacterial cell wall; work best against gram (+) bacteria spla2 pokes holes in the lipid membrane, cleaves the phospolipid at carbon 2 to produce lyso phospholipid and a fatty acid membrane becomes leaky. Defensins and cathelicidins amph oligomyze and form a pore. Within granules = defensins, nadph oxidize, fe binding proteins, mpo, proteases. Electron transferred to ozygen = superoxide catalyzed by nadph oxidaze; plus a h+ Inability to produce the bleach due to a mutaiton in nadph oxidase p91 = x linked.
