Immune Study Notes Lecture 2.docx

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Microbiology and Immunology
Microbiology and Immunology 3300B

Immune Study Notes Lecture 2 Describe the epithelial barrier. Epithelial has tight junctions that don’t allow anything through. Within the epithelium in the lungs, goblet cells secrete secretory vesicles that secrete mucous to the luminal space. Mucous collects dust and the cilia move it out of the airway. In the gut, there are invaginations with anti pathogen proteins and nutrients can also get across. Microvilli are the main component here. Goblet cells also secret emucuos in the gut. In the skin epithelium there are cells that secrete oils to the skin – also cells differentiate as you move up; lots of keratin (dead cells). 1. What are the chemical defenses of the epithelium? Lysozymes – break the bacterial cell wall; work best against gram (+) bacteria sPLA2 – pokes holes in the lipid membrane, cleaves the phospolipid at carbon 2 to produce lyso phospholipid and a fatty acid – membrane becomes leaky Defensins and Cathelicidins – AMPH – oligomyze and form a pore C-type lectins – bind to unique carbohydrates and break the membrane 2. What receptors are involved in detection of self? Sialyic Acid, M
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