Immune Study Notes Lecture 3.docx
Immune Study Notes Lecture 3.docx

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Western University
Microbiology and Immunology
Microbiology and Immunology 3300B

Immune Study Notes Lecture 3 1. Where are most immune cells? Within the circulation. Where are immune cells made? In the bone marrow; but in children in the yolk sac then liver then bone marrow. What are immune cells found? -tissue, blood, lymph, peripheral organs (lymphnodes/tonsils/adrenoid/spleen), central lymphoid organs (thymus and bone marrow) What is Bone Marrow? Spongy connective tissue of the long bones – contains immune cells, red blood cells, fat and connective tissue Explain the blood/lymph system. Circulation occurs, blood lets fluid seep out of the capillaries into tissues – gathers with antigens. Antigens/fluid from lymphatic tissues put into lymphatic vesicles and brought to peripheral organs for antigen presentation – then put back into the circulatory system. What is the composition of the blood? Plasma, buffer and red blood cells. In the buffer – PMN – polymorphonuclear cells: neutrophils, eosonophils and basophils. Mononuclear cells = lymphocyts and monocytes What is hematopoesis? Progenitor cell is pluripotent and can differentiate into different types of cells. Capable of infinite proliferation although they stop because you only need so many. 2. What are the lymphoid cells? B/T/NK cells B/T cells a part of the adaptive immunity – see antigen and start producing antibodys T cells need to be presented with an antigen to start immune response CD4+ = immune response CD8+ = apoptosis – going to kill if it doesn’t have the right amount of MHC complex All proliferate and become active once they’ve come into contact with the antigen *upon presentation they differentiate NK cells have the granules – pro-apoptotic and pore forming molecules; also recognize MHC How do you form platelets and RBC? Progentiro – megakaryocyte = platelet (no nucleus) Progenitor – erythroblasts – shoots nucleus out = erythrocyte 3. In RBC – if there is a nucleus present; what might this suggest? Hemapoeitc disorders or anemia, or you could be a camel or lama What are erythocrytes? RBC – bring O2/CO2 – no known immue function, long half life – 100 – 120 days, circulate every 20s Hematopoietic stem cell – turns into myeloid pregenitor cells = macrophage/granulocyte progenitor = in the blood: eoso/baso/neutro/mono then in tissues macro or mast cells Myeloid can tur
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