Microimmune Lecture 9 Study Notes
1. When does development of the Ig chains take place?
First the J-D regions recombine, then the V with the DJ segments, then the light
chains can recombine. Light chains kappa and lamba do not recombine until the
heavy chains have.
2. What are immunoglobin isotopes?
We have many different forms of Ig that serve different functions. They are arranged
along a gene segment that looks like a bunch of exons and introns. IgM is always
first towards the 5’ end (human and mouse) and IgA is always towards the 3’ end.
Only difference is the number of Igs within the gene segment.
3. Discuss the J chain secrete form.
IgA can be secreted as dimeric – held head to head by a J chain through non covalent
bonds. IgM can be secreted as a pentameric form through a J chain as well.
4. What are some immunoglobin functions?
IgM, IgG1/3 are good for activating the classical pathway. IgG1/3 are good for
placental transfer of nutrients. IgE is important in receruitment of mast
5. What receptors interact with the constant region of an antibody?
6. Why do we give so many doses of a vaccine?
Because the first doesn’t provoke a strong enough immune response.
7. What changes over the course of responses?
In the first response; there is a time lag, then a