Microbiology and Immunology 3300B Study Guide - Final Guide: Blood Type, Xenotransplantation, Haplotype
29 Mar 2013
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Autograft: self grafting (taking out bm and putting it back in) Antibody mediated (c" and fcrs/nk cells) going to bind the vascular endothelium of the graft an initiate an inflammatory response, occluding the blood vessels. The antibodys must be preexisting: discuss blood typing. Blood transfusions are the most common transplantation done. Blood type is determined by the carbohydrates found on your cells. If your o you don"t have any antibodies (your anti a and b: discuss hyperacute rejection and the xenograft. Human donors are limiting so we look to other sources for compatible tissues. Alternative pathway of compliment activation: get a tick-over of c3 activation where it become semi activated and inserts into a membrane near by. But we have proteins such as daf to fix this. Regulatory proteins that are conserved aren"t identical across species. Make it so that it is alpha gal deficient and make a human form of daf.
