Microbiology and Immunology 3300B Study Guide - Final Guide: Reactive Oxygen Species, Mycobacterium Leprae, Chemokine
29 Mar 2013
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Wound healing induced, complement destruction (picked up by macrophages/dc in the tissue) Dc migrate to lymphnodes, phagocytosis, nk cells activated, cytokines and chemokines produced. Initial infection is in the gi tract and largely asymptomatic (infects us at very young age; contaminated water or food) Almost everybody has it but it doesn"t harm its host; good at spreading; live long infections. Infection is very rare, occurred in the 1970s. Person-to-person transmission is rare: this is because rapid death is caused; otherwise the virus is easily spread. Persistent/latent infections do not occur: discuss evolution of malaria/o type etc. Humans and chimps diverge from the same common ancestor. We developed the o blood type after splitting from chimps 5 mya. Begin to see mutations protecting us against malaria in the areas where it is endemic; as humans migrate out of africa 80 000 ya. Malaria evolving in response to these changes: discuss the evolution of hiv.
