Microbiology and Immunology 3300B Study Guide - Final Guide: Death Domain, Aldehyde, B Cell
29 Mar 2013
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Document Summary
Central tolerance (occurs in the bone marrow and thymus); deletion and editing. Antigen segregation (peripheral organs); physical barrier to self antigens; access to lymphoid system. Peripheral anergy (secondary lymphoid tissue) cellular inactivation by weak signaling without co-stimulus. Regulatory t cells (secondary lymphoid tissues and sites of inflammation) suppression by cytokines, intercellular signals. Functional deviation (secondary lymphoid tissues and sites of inflammation) differentiation of reg t cells that limit inflammatory cytokine secretion. Activation-induced cell death (secondary lymphoid tissues at sites of inflammation) Most self antigens are retained outside of the lymphoid system by physical barriers (cell membranes/endotheliums) Our immune system is actively excluded from these tissues: describe immune privileged sites, Sites capable of tolerating the introduction of an antigen without eliciting a damaging immune response. Restricted entry of immune cells blood brain barrier. Expression of class 1b mhc in preference to classical mhc1 tend to present formyl peptides not self antigens. Constitutive expression of apoptosis-inducing ligands (fasl and trail)
