Pathology 3245B- Final Exam Guide - Comprehensive Notes for the exam ( 53 pages long!)

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Infections e. g. hpv: various dermatologic conditions, neoplastic, vulvar intraepithelial neoplasia, squamous cell carcinoma. Lichen sclerosus: skin condition relatively localized to vulvar and perianal area, most common: elder women, looks like, flattening of normally present folds - loss of labial folds, atrophy, pale / symmetrical (like rorschach) Increased risk of vulvar cancer but is not a precursor lesion. Mitosis occurs throughout all layers: behavior and treatment, persistence or recurrence is common, hpv-related, progression to invasion in about 10 15% patients, p53 related vin, progression to invasion in 60-80% of patients! Vin has a risk of progression to squamous cell carcinoma of the vulva: treatment, surgical excision usually, sometimes radiation added. Cervical cancer: usually squamous cell carcinoma (90%, often asymptomatic, sometimes have post-sex/coital spotting, patterns of spread, local invasion, lymph nodes, adjacent structures, treatment: If biopsy comes back with high grade lesion: cone biopsy (upper left: hysterectomy (in more serious cases, upper right, radiation therapy (good for squcecas)

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