Pharmacology 2060A/B Study Guide - Pharmacokinetics, Pharmacotherapy, Blood Proteins

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The underlying principle of clinical pharmacokinetics is that a relationship exists between the effects of a drug and the concentration of drug in the body. In clinical pharmacokinetics we try to provide: a quantitative relationship between drug dose and effect, a framework to interpret measurements of drug concentrations in biological fluids to benefit patient drug therapy. Clearly taking a sample from a patients" brain to measure drug concentrations is invasive and would likely do more harm than good. Plasma is a good concentrations because: site to measure drug: it is relatively non invasive, for most drugs there is a good correlation between plasma concentration and therapeutic and toxic drug effects. In reality, measuring free drug concentration is difficult and tedious so total (free + protein bound) concentration is usually measured. For most drugs, measuring total plasma concentration provides enough information to guide drug dosing.

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