Pharmacology 3620 Study Guide - Midterm Guide: Antidepressant, Mannitol, Irreversible Antagonist

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 3620
• Professor: Rommel Tirona

Document Summary

N-acetylcysteine: creates gsh for gst metabolism/glutathione conjugation of napqi created from acetaminophen overdose. Digoxin: excreted via urine; substrate for efflux p-gp/mdr1. Quinidine: blocks p-gp & mdr1 such that digoxin cannot be excreted. Penicillin: excreted by urine; substrate for oat. Probenecid: blo(cid:272)ks oat su(cid:272)h that pe(cid:374)i(cid:272)illi(cid:374) (cid:272)a(cid:374)"t (cid:271)e uptake(cid:374) i(cid:374)to the kid(cid:374)e(cid:455) for e(cid:454)(cid:272)retio(cid:374) Cyclosporin a: blocks p-gp channels on bbb such that verapamil cannot be excreted/remains in the brain. Aspirin: an irreversible antagonist which acetylates a serine residue in the active site of cox1 in platelets such that arachidonic acid metabolites cannot be synthesized and an inflammatory response cannot occur. Protamine sulfate: a positively charged chemical agonist which can sequester heparin overdose. Beta-blocker: slows down heart rate; a functional agonist which can be used to treat tachycardia a side effect of hypothyroidism. Benzodiazepines: enhances gaba inhibitory effects on gabaa receptor by causing lots of receptors to open, and more cl- to enter.