Pharmacology 3620 Study Guide - Spring 2018, Comprehensive Midterm Notes - Metabolism, Liver, Enzyme
12 Oct 2018
School
Department
Course
Professor
Pharmacology 3620
MIDTERM EXAM
STUDY GUIDE
Fall 2018
Lecture 001: Introduction to Pharmacokinetics
● Membrane Permeability of Drugs
Objectives
● Describe how pharmacokinetics relates to overall drug effects.
● Describe the tissue barriers that influence drug disposition (absorption, distribution,
metabolism, elimination) in the body.
● Name the pathways for drug movement across a membrane.
● Define and understand the chemical characteristics of drugs that influence the rate of
passive membrane diffusion.
● Define biochemical features of facilitated membrane transport.
The goal of drug therapy is to prevent, cure or control various diseases.
Elements of the doctor’s prescription
Dose depends on:
● Size of person
● Strength of symptoms
Route of Administration
● Metabolism in liver
● Chronic drug intake
● Easier than needles
What are drugs?
● 4 basic types by chemical composition
● Small Molecules
○ Organic
○ 300-900 Da
find more resources at oneclass.com
find more resources at oneclass.com
○ Majority of drug prescribed (although their usages is decreasing)
● Peptides
○ Small chains of A. A. (up to tens)
○ Small peptidic hormones
● Proteins
○ Large chains of A. A.
○ Enzymes
○ Hormones
○ Antibodies
■ Immunoglobulins that target specific things
● Oligonucleotide
○ Antisense therapeutics
○ Binds RNA to alter gene
expression in the cell
○ Only 1 available on the
market
Drug Names
● Generic Name is the one we
are using
Definitions
● Pharmacokinetics:
○ What the body does to the drug.
○ metabolism
● Pharmacodynamics:
○ What the drug does to the body.
○ Targets
Pharmacokinetics (PK)
● Quantitative description of a drug concentration in the body over time
● The pharmacokinetics of a drug, administered via a specific route, in parts the optimum
dose
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Describe how pharmacokinetics relates to overall drug effects. Describe the tissue barriers that influence drug disposition (absorption, distribution, metabolism, elimination) in the body. Name the pathways for drug movement across a membrane. Define and understand the chemical characteristics of drugs that influence the rate of passive membrane diffusion. Define biochemical features of facilitated membrane transport. The goal of drug therapy is to prevent, cure or control various diseases. Majority of drug prescribed (although their usages is decreasing) Binds rna to alter gene expression in the cell. Generic name is the one we are using. What the body does to the drug. What the drug does to the body. Quantitative description of a drug concentration in the body over time. The pharmacokinetics of a drug, administered via a specific route, in parts the optimum dose. The relationship between the dosage regimen of the drug and the blood concentration of the drug.
