Physiology 3140A Study Guide - Final Guide: Protein Kinase A, Adenylyl Cyclase, Voltage-Dependent Calcium Channel
3 Jul 2017
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Degraded: synthesized from atp by plasma membrane-bound adenylate cyclase, removes 2 phosphates from atp and cyclizes it. It is made intracellularly (within the cytoplasm of the cell: camp has biological activity, degraded to 5"-amp by cyclic amp-specific phosphodiesterase (breaks the ring open, 5"-amp has no biological activity camp as a signalling molecule. In a normal resting cell there is very little conc. of it (10-7m) can rapidly increase or decrease in response to extracellular signal. Recall: role of camp, pka in regulation of biological activity of cytoplasmic proteins. Step by step process (review): ligand (in this case hormone) binds to gpcr, this activates g proteins (can be gs or gi, each g protein has alpha and beta subunits. In this case g s is activated activates its effector (adenylate cyclase: results in production of camp, camp binds to regulatory subunits of pk-a, catalytic subunits free and phosphorylation of cellular proteins occurs.
