Study Guides (390,000)
CA (150,000)
Western (10,000)
PHYSIO (300)
Final

Physiology 3120 Study Guide - Final Guide: Endothelin, Xerostomia, Reticular Formation


Department
Physiology
Course Code
PHYSIO 3120
Professor
Tom Stavraky
Study Guide
Final

This preview shows pages 1-3. to view the full 115 pages of the document.
Endocrine)Physiology:)
!
- Hormone!classes:!
o Peptide:!water!soluble!
o Steroid:!water!insoluble;!need!carrier!protein!
o Amino!acids!derivatives:!catecholamines,!T3/T4;!water!insoluble!!
- Negative!feedback:!between!two!hormones!or!one!hormone!one!metabolite!
- A!single!hormone!might!elicit!different!effect:!Testosterone!and!DHT;!spermatogenensis!and!increase!
muscle!mass!
- SCN:!provides!circadian!timing!to!the!hypothalamus!
o Clock!genes:!Per!&!Cry!
o Respond!to!non-visual!signal!from!retina!
o Non-visual!signal>!SCN>!spinal!cord>!Pineal!gland>!Melatonin>!reset!SCN!
o Melatonin:!decrease!body!temperature,!increase!drowsiness,!inhibit!clock!genes!production!
- Hormone!action!is!affected!by:!
o Hormone!production!
§ Peptide:!pro-hormone!à!modification!à!package!in!granules!in!Golgi!à!Ca!release!
§ Steroid:!synthesis!form!cholesterol!(CYP!protein!in!ER!and!mitochondria)!
o Binding!protein!(CBG,!SHBP)!stability,!bioavailability,!clearance,!metabolism!
o Converting!or!deactivating!enzymes!(COMT,!aromatase,!5!alpha-reductase)!
o Hormone!receptor!
§ Steroid!hormone:!nuclear!receptor!(co-activator!or!co-repressor)!
§ Peptide!hormone:!cell!surface!receptor!
GPCR!
Receptor!tyrosine!kinase!
Ion!channel!
Tyrosine!kinase!associated!receptor!
- Hypothalamus!neurons:!
o Parvicellular!neuron:!hypophyseo!portal!system,!anterior!pituitary,!short!
o Magnocellular!neuron:!posterior!pituitary!,!long!
o Hypothalamic!projection!neuron!
!

Only pages 1-3 are available for preview. Some parts have been intentionally blurred.

- Major!hypothalamic!factors:!most!are!peptide!hormones!except!for!Dopamine!
- Somatotropin!release!inhibiting!factor!(SRIF):!inhibit!release!of!TSH,!GH!
- Prolactin!can!be!stimulated!by:!TRH,!PRF;!inhibited!by!dopamine;!
!
!

Only pages 1-3 are available for preview. Some parts have been intentionally blurred.

!
!
!
You're Reading a Preview

Unlock to view full version