BI110- Final Exam Guide - Comprehensive Notes for the exam ( 67 pages long!)
Document Summary
Certain receptors bind and react to certain binding sites. Binding of the signal causes conformational change in receptor. Enzyme binding to allosteric enzyme(2nd binding site)(changes to shape) --analogy. Change in conformation and changes it to active. Can be 3 can be 12--enzymes being activated. Response needs to turn off in order to respond again--shut down response. Switch active to inactive in multiple ways--not just the one enzyme. Binding to receptor is reversible-- receptor isn"t bound--continuously binding and releasing to signalling molecule. Response is determined how much time is spent in active and inactive form. At least 3 things must happen to turn off. Some signaling molecules may need to travel great distances in the body through the circulatory system. Endocrine signalling -- signal travels through the circulatory system. Singla need to travel a long distance. Paracrine signalling involves two cell that are close to each other. In paracrine signaling, the signal is usually a small, soluble molecule eg. growth factors.
