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Glycolysis.docx

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Department
Biology
Course
BIOL 2905
Professor
Tanya Da Sylva
Semester
Fall

Description
Glycolysis In glycolysis, the six-carbon glucose molecule is broken in half into two three-carbon molecules. This process uses two ATP units and creates four ATP units, for a net production of two ATP molecules. At the end of glycolysis, the molecules can become lactic acid, or lactate, and exit the cell, or become pyruvate and enter the next part of anaerobic glycolysis called the tricarboxylic acid cycle. Three stages: glycolysis, Krebs cycle, and the electron transport chain Glycolysis--enzymatically converts glucose through several steps into pyruvic acid. May be only the first phase of aerobic respiration or it may serve as the primary metabolic pathway (fermentation). Provides significant means to synthesize small mount of ATP anaerobically and to generate pyruvic acid--an essential intermediary metabolite. Process proceeds along 9 steps. Starts w/glucose. Ends with pyruvic acid (pyruvate). Each of 9 reactions catalyzed by specific enzyme w/a specific name. (1) glucose activated by addition of phosphate, results in glucose-6-phosphate. (2) glucose-6-phosphate then converted to fructose-6-phosphate (3) phosphate added to fructose-6-phosphate forming fructose diphosphate--more symmetrical and can be split (which it is) into two 3-carbon molecules. No oxidation-reduction has occured and 2 ATP already used. (4) The two 3-carbon molecules are isomers (molecules or molecular compounds similar in that they have the same molecular formula, however have different arrangements of the atoms or groups of atoms (functional groups) involved) of each other. Next step converts the one Dihydroxyacetone phosphate (DHAP) to glyceraldehyde-3-P (G-3-P) resulting in two G-3-Ps. All subsequent steps happen twice (one to each of the 3-C molecules) (5) First, the G-3-Ps each receive another phosphate. At same time, 2 NADs in the vicinity are reduced to NADHs. NADHs will be used in last step of catabolism (the electron transport system) to produce ATP. In the la
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