KINE 2011 Study Guide - Final Guide: Gaba Receptor, Alprazolam, Commissure

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Published on 16 Oct 2011
School
York University
Department
Kinesiology & Health Science
Course
KINE 2011
Professor
24/11/2010, 9:33 AM
Dopamine
Cocaine inhibits its reuptake by competing with the transporter in charge of this reuptake process
Dopamine continues to activate certain neurons among them
This plays a role in emotional responses, especially feelings of pleasure
Amino Acid Neurotransmitters
GABA (gamma-aminobutyric acid)
Major inhibitory neurotransmitter in the brain
Benzodiazepine drugs (Xanax, Valium) increases chloride flux through GABA receptor
This reduces anxiety, protect against seizures, help to sleep
Tetanus toxin - prevents the release of GABA from presynaptic element; consequences?
No inhibition
Intense muscle contraction (could break your bones)
Can lead to fatality (500 000 people die a year)
Neuropeptides
Small size
Trigger the opening of channels in a few msec
Synthesized in the presynaptic region and packaged in synaptic vesicles
Neuropeptides:
Synthesized in cell body
Larger molecules
Notion of Convergence and Divergence
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