KINE 3012 Study Guide - Final Guide: Nan, Atelectasis, Sodium Bicarbonate
Document Summary
Renal&artery& afferent&arteriole& glomerulus&& efferent&arteriole& & peritubular&capillaries/& vasa&recta&& venules&& renal&veins& Map& gfr& salt&delivery&in&distal&tubule& macula&densa& release&atp& extracellular& degradation&of&atp&forms&adenosine& acts&locally&to&vasoconstrict&afferent&arteriole& gfr&to&normal. Tubular&reabsorption: occurs&in&proximal&tubule&(small&ions&and&molecules&are&removed&from&kidneys& to&be&reabsorbed&by&rest&of&body, sodium&pumps&are&on&outer&surface&of&kidney&tubule&(surface&faces&interstitial& fl, na+&move&from&filtrate&into&tubule&cells. &na+&pump&actively&transports&na+&into& interstitial&fluid, interstitial&fluid&becomes&high&in&na+&conc&than&peritubular&capillaries. & na+& moves&passively&into&the&capillaries, negatively&changed&ions&(cl< &&bicarbonate)&follow&na+&into&interstitial&fluid&and& back&into&blood, water&follows&passively&down&this&osmotic&gradient, amounts&of&na+&and&h2o&reabsorbed&are&under&hormonal&control&and&can&be& adjusted&to&maintain&the&solute&conc&of&extracellular& fluid& Transfer both na+ and speci c organic molecules. Transports k from lateral space into tubule cells. # carriers limits amount of substance than can be transported. They are excreted/ moved out into urine. All actively reabsorbed substances have tm except. Plasma conc of some carrier-limited substances are regulated by kidneys but not all. Tm of glucose is higher than normal so it is not regulated (doesn"t reach saturation) Renal&threshold& plasma&conc&at&which&tm&of&substance&is&reached&and& substance&appears&in&urine: increase&in&phosphate&&(e. g&thru&diet)& increase&amount&of&phosphate&excreted& in&urine&to&restore&plasma&conc&to&normal, reabsorption&is&subject&to&hormonal&control&(parathyroid&hormone&can&alter& renal&thresholds&depending&on&need) 65% are reabsorbed in proximal tubule, collecting duct and loop of henle. Na, cl and h20 reabsorbed at similar rates. Descending loop of henle is permeable to h2o but no na reabsorption. Ascending loop of henle is impermeable to h2o but allows na reabsorption (controlled by aldosterone)