[NATS 1670] - Final Exam Guide - Comprehensive Notes fot the exam (58 pages long!)

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NATS 1670
FINAL EXAM
STUDY GUIDE
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Lecture 1
Activate blood coagulation
- Eventually lead to lack of the coagulating factors
- Internal bleeding
- Asymptomatic (most cases)
- Persistent (chronic) disease
- Can infect other people
- HBV
- Suffering, followed by recovery
- Kill the infected person
- Congenital disease
- Neonatal disease
- Contributory factor in several diseases
- Contributory factor in cancer
HIV/AIDS
History of an Infectious Agent
- Monkeys to human beings around 1930s
- Most likely occurred due to butchering
- Brazzaville, Congo (1929)
- Virus was local in small cities
- HIV made its way through drug type
- January 10, 1981
- Dr. Gottlieb office at UCLA Medical Center
- Patient with Labial herpesvirus
- Caused by fungi, a type of yeast
- In LA 1967-1978
- there were only two cases of PCP in immunocompromised patients
- 1981, LA 5 cases of PCP
- All considered w/ young people
- Homosexual males
- Early 1970s 5 cases/yr of Kaposi’s sarcoma (KS)
- 1981 26 cases of Kaposi’s sarcoma
- San Francisco and NY
- Young people
- Homosexual males
- Aggressive cancer
Epidemiology of a New Disease
- Two rare diseases
- Opportunistic infection (PCP)
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- Rare cancer (KS)
- Plus other conditions linked to immunosuppression
- Clusters of infected gay men
- Concentrations within sexually interactive groups
- Suggests an infectious agent
- Sexually transmitted within the gay population
- Original Name of Disease: Gay-Related Immune Deficiency (GRID)
- Other ways of getting a similar syndrome
- Intravenous drug use
- Blood transfusions
- Hemophilia A (coagulation factor VIII)
- Female sex partners of AIDS-positive, IV drug users and hemophiliacs
- Acquired Immune Deficiency Syndrome (AIDS)
AIDS Statistics (2010)
-Sub-Saharan Africa
- About 1.9 million new cases of HIV infection per year
- 350,000 are children
- 1.2 million death every year
- Approx. 23 million people are infected right now with HIV
- 3.1 million are children
- Several countries in sub-Saharan Africa report infection rates of 20-35%
AIDS/HIV in Western Countries the United States as an Example
- Over 1 million people have diagnosed with AIDS s USA since 1981
- At least 600,000
- An estimated 1.3 million in the US are infected with HIV
- ~27% undiagnosed and unaware of their HIV infection
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Document Summary

Eventually lead to lack of the coagulating factors. Hiv made its way through drug type. Dr. gottlieb office at ucla medical center. Caused by fungi, a type of yeast. There were only two cases of pcp in immunocompromised patients. 1981, la 5 cases of pcp. Early 1970s 5 cases/yr of kaposi"s sarcoma (ks) 1981 26 cases of kaposi"s sarcoma. Original name of disease: gay-related immune deficiency (grid) Other ways of getting a similar syndrome. Female sex partners of aids-positive, iv drug users and hemophiliacs. About 1. 9 million new cases of hiv infection per year. 23 million people are infected right now with hiv. Several countries in sub-saharan africa report infection rates of 20-35% Aids/hiv in western countries the united states as an example. Over 1 million people have diagnosed with aids s usa since 1981. An estimated 1. 3 million in the us are infected with hiv. ~27% undiagnosed and unaware of their hiv infection.

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