NATS 1670 Study Guide - Midterm Guide: Frameshift Mutation, Lung Cancer, Nonsense Mutation
19 Sep 2016
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Sc/nats1670 concepts in human health and disease. Topics to study: translation, mutations, cancer, immune system, vaccination and passive immunization. In the living cells, dna undergoes frequent chemical change, especially when it is being replicated. Most of these changes are quickly repaired. We are different from one generation to the other. It helps us to do better and cope with the changing environment. Those that are not repaired quickly result in a mutation. Thus, mutation is a failure of dna repair. Mutation can result from the incorporation of incorrect bases during dna replication. Most spontaneous changes in dna are temporary because they are immediately corrected by processes collectively called dna repair. Most damage to dna is repaired by removal of the damaged bases followed by resynthesis of the excised region. Human dna of one cell is 2 meters long. 1016 cells are produced in a human lifetime. Human dna 2 meters long packed into the nucleus (0. 006 mm) of a cell.
