BME 318 Study Guide - Midterm Guide: Complement Component 5A, C3B, Chemotaxis
Document Summary
Variable (custom) invariant (generalized) later, highly specific early, limited specificity. Characterized by: damage, platelets, plug, prothrombin, thrombin, fibrinogen, fibrin net. Single bilayered membrane with thick wall of peptidoglycan, mediators for binding to ecm. Growth of organisms on skin: example is burn dressing: deep immediate infection. Presence of infection at implant site after surgery: late infection. Infection occurs months to years later cause is unknown. Biofilm is a protector of pathogen from phagocytosis by neutrophil or macrophage. Traps ion for bacterial survival, physical barrier to host response: dispersion. Shear force carries portion of colony to other areas. Microorganism attachment influenced by the characteristics of: (1) microorganism surface, (2) biomaterial surface, and (3) surrounding solution (media) Two types of acquired immunity: hemoral: actions of antibodies to fight off foreign substances, cellular: utilizes t cells to detect altered self cells. B cell antigen receptor is membrane bound antibody.
