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Chapter 8.5 Notes.docx

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Boston University
CAS BI 108
Francis Monette

8.5: How are EnzymeActivities Regulated? - In metabolic pathways the product of one reaction is the reactant for the next. Each reaction is catalyzed by a specific enzyme. - The amount of enzyme activity is controlled by the regulation of the gene expression. Signal transduction pathways end with gene expression and genes are switched on/off to encode enzymes - Control by activating or inactivating existing enzymes Enzymes can be regulated by inhibitors Inhibitors can bind to enzymes and slow down the rates of the reaction. Naturally occurring inhibitors regulate metabolism; artificial ones for disease, killing pests Removal of a natural reversible inhibitor increases an enzymes rate of catalysis Irreversible Inhibition: when inhibitor covalently binds to certain side chains on the active site, it will permanently inactive the enzyme so it cant interact with the substrate. Reversible Inhibitions: inhibitor is similar to enzymes natural subs
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