8.5: How are EnzymeActivities Regulated?
- In metabolic pathways the product of one reaction is the reactant for the next.
Each reaction is catalyzed by a specific enzyme.
- The amount of enzyme activity is controlled by the regulation of the gene
expression. Signal transduction pathways end with gene expression and genes
are switched on/off to encode enzymes
- Control by activating or inactivating existing enzymes
Enzymes can be regulated by inhibitors
Inhibitors can bind to enzymes and slow down the rates of the reaction. Naturally occurring
inhibitors regulate metabolism; artificial ones for disease, killing pests
Removal of a natural reversible inhibitor increases an enzymes rate of catalysis
Irreversible Inhibition: when inhibitor covalently binds to certain side chains on the active site,
it will permanently inactive the enzyme so it cant interact with the substrate.
Reversible Inhibitions: inhibitor is similar to enzymes natural subs