Drug is a substance that changes the bodily function upon entry.
Psychoactive Drug specifically has a phycological effect; changes behavior.
Psychopharmacology - study of psychoactive drugs and their action. Greek pharmakon - poison
FDA - administration responsible for the regulation of pharmacological drugs
Potency - is how effective a drug is, Affinity - Ability to bind to a receptor
Selectivity - Ability to bind to specific receptor Efficacy - Ability of binding to influence behavior
agonist – Increase effects of neurotransmitters antagonist – decrease effects of neurotransmitters
Tolerance – Need more to get effect. Sensitivity – Need less to get effect
Differential Tolerance – Tolerance to some effects but not all.
Therapeutic Index - The distance between the lethal dose and effective dose
Pharmacokinetics - What the body does to the drug.
Pharmacodynamics - What the drug does to the Body
neurotransmitter synthesis – chemicals combine to form neurotransmitters
L-Dopa – makes dopamine – agonist
Synaptic Vesicles – Carries neurotransmitters into synapse
Monoamine Oxidase (MAO) – Breaks Down monoamines - Pacman – agonist.
MAOI – shuts off the MAO the shutter offer, Pacman – agonist.
Receptors – Intake Neurotransmitter Reuptake transporters
Acetylcholinesterase - Second “Pac man” in synapse, eats access acetylcholine?
Auto receptors - “thermostat”, regulates how much needs to be released?
Anxiolytics - drugs used to reduce anxiety – Barbitur