Study Guides (299,438)
US (149,829)
Brown (44)
BIOL (22)
Midterm

BIOL 0170 Study Guide - Midterm Guide: Hemodialysis, Anticoagulant, Calcification

7 pages48 viewsFall 2013

Department
Biology
Course Code
BIOL 0170
Professor
Beth Zielinski
Study Guide
Midterm

This preview shows pages 1-2. to view the full 7 pages of the document.
Shortened study sheet (study at your own risk)
PPT1: organ transplantation
UNOS (United network of organ sharing)
o120078 on waiting list
o77067 active waiting list candidates
o16669 transplants jan-july
o8215 donors jan-july
Transplantation
oAutologous
From yourself
oIsogeneic
From identical twin or genetically identical
oAllogeneic
From same species
oXenogeneic
From different species
Immune recognition
oMHC/HLA (human leukocyte antigens)
Immune recognition
Hyper/acute/chronic rejection
oABO
Hyperacute rejection
Blood type
MHC/HLA
oCell surface antigens
o200 genes on chromosome 6
o3 classes
class 1: cell surface antigens
class 2: immune cells
class 3: complement system components
ocombination of HLA makes you unique
Testing for a match
oABO blood tests
Test rbcs
oMixed leukocyte culture
Test wbcs
oSerological cross-matching
Serum Ab-antigen testing for both ABO and HLA
oDNA typing
Allele mismatches
Rejection reactions
You're Reading a Preview

Unlock to view full version

Only half of the first page are available for preview. Some parts have been intentionally blurred.

oPatients need to match according to HLA tissue typing
Closer match  more well tolerated
Only identical twins are complete match
Blood type must match too
oDirect pathways
Acute rejection (right away)
T-cells recognize foreign HLA
oKILLLLLL
oIndirect pathways
Chronic or late rejection
oGraft vs host response
Donated cells view host as enemy, KILLLLLL
oHyperacute rejection
Within first 48 hrs
Antibody-mediated
Caused by pre-existing antibodies in recipient
Fever and anuria
oAcute rejection
Within first 6-90 days
Lymphocytes activated against donor antigens
Anti-donor antibodies developed
oChronic rejection
Months to years
Antibody and cell-mediated
Fibrosis and scarring
Immunosuppressive therapy
oMedication
Can cost up to 2500/month
Companies/groups
oUNOS (united network for organ sharing)
oOrgan Procurement Organizations
Buying/selling organs irregal in states
Kidney transplants
o14000 transplants/year
o2000 organs/year
onumber has remained relatively constant
DONOR AND RECIPIENT DO NOT DEAL DIRECTLY WITH EACH OTHER
oIS BAD. IRREGAL. BAD.
Go through transplant centers, organ procurement organizations
PPT2: organ transplantation 2
Face transplants
oFirst successful one in 2005
oIsabelle dinoire
You're Reading a Preview

Unlock to view full version


Loved by over 2.2 million students

Over 90% improved by at least one letter grade.