BIOL 0170 Study Guide - Coronary Artery Bypass Surgery, Autotransplantation, Xenotransplantation
2 Apr 2014
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Ppt 1: organ transplants 1: unos (united network for organ sharing, 120,000 patients on transplant list, 16000 transplants from jan july, 8000 donors jan july, transplantation, autologous. Too different: no way to make transplant work: hla 1: nucleated cells, hla 2: immune cells, hla 3: encode complement components, testing for match, abo blood test. Hyperacute rejection: within 48 hours, fever and anuria, recipient has preformed antibodies, always inflammation initially, graft vs host reactions always possible. Cytokine receptor signal transduction inhibitors: block cytokine synthesis, history, 1954: first living kidney transplant, 1962: first cadaveric kidney transplant, 1963: first lung transplant, 1967: first liver transplant, 1967: first heart transplant, 1968: uniform gift act: uniform donor card: legal document for 18+ to legally donate organs upon death, 1972: end stage renal disease paves way for dialysis + kidney transplant to be covered by medicare, 1981: first successful heart/lung transplant, 1983: fda approves cyclosporine, 1984: unos established.
