CHEM 3570- Final Exam Guide - Comprehensive Notes for the exam ( 30 pages long!)
29 Mar 2018
School
Department
Course
Professor
Document Summary
Sn2 reactions: rate law and mechanism rate=k[reactant1][reactant2] Reveals details of reaction mechanism: what"s in rate determining step: occur in a single step with inversion stereochemistry (two arrows) It occurs when an alkyl halide reacts with a good nucleophile. Relative rates of sn2 rxns and bronsted acid-base reactions. If an alkyl halide and a bronsted acid are in competition for a bronsted base, the bronsted acid reacts more rapidly. Effect of alkyl halide structure on the sn2 rxn. If both paths occur at equal rates, a racemate occurs. Increased alkyl substitution at the beta-carbon retards reaction. Due to van der waals steric effect (hydrogens interact alot) In secondary and tertiary alkyl halides, sn2 competes with elimination reactions. Tertiary alkyl halides almost always undergo elimination rxns. The bronsted basicity ( how willing it is to accept h+) of the nucleophile. The solvent in which the reaction is carried out. Bronsted basicity and solvent effects on nucleophilicity.
