Can anyone help me answer these in detail please. These are part of material i need to know for my next exam and have no clue about them and cant find anuthing in our lecture notes about them
1. Clonal sequencing methods vs. Shotgun sequencing methods. What are the differences, pros and cons of each?
2. Local vs. Global alignment. Understand the theory of the alignment methods that underlie these types of alignment and be familiar with Needleman–Wunsch and Smith-Waterman.
3. Identify a strand based on the frame (+/-) and what a six-frame translation means
4. What types of sequences are the majority found in GenBank