MCDB 2150 Study Guide - Midterm Guide: Caat Box, Alternative Splicing, Tata Box
2 Mar 2017
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Unit 2 extra practice problems: mutagenic studies of the promoter region of the -globin gene indicate that mutations in some areas are more likely than mutations in other areas to affect transcription rates. When mutations occur in consensus sequences (modular elements such as gc box, Methylation within the transcription unit (rather than outside it: at very high levels of methylation (593 cpgs), which of the following is true. Methylation has the same effect regardless of region: it has been estimated that at least two-thirds of human genes produce alternatively spliced mrna isoforms. In some cases, incorrectly spliced rnas lead to human pathologies. Scientists have examined human cancer cells for splice-specific changes and found that many of the changes disrupt tumor-suppressor gene function (xu and lee, 2003. A variety of nonsense products, which result in premature rna decay or truncated protein products. Cancer-specific splices can be result of tumorigenesis.
