HSCI 301 Midterm: Exam 2

• School: Drexel University
• Department: Health Sciences
• Course: HSCI 301
• Professor: William D' Andrea

Document Summary

Adrenergic agonists: stimulated by norepinephrine (noradrenaline) or epinephrine (adrenaline: sympathomimetics stimulate adrenergic receptors. Can be directly or indirectly (by enhancing release or blocking reuptake of norepinephrine) Adrenergic neuron: releases ne in the cns and sympathetic nervous system (in ganglia and effector organs: neurotransmission: Synthesis in adrenal medulla and postganglionic neurons in sympathetic nervous system by tyrosine (amino acid) Tyrosine makes l-dopa which makes dopamine which is converted to ne when it gets into the storage vesicle. Release of ne when ca2+ floods the cell. Removal from synaptic cleft by reuptake into storage vesicle. Can be inactivated/methylated by comt (catechol-methyl transferase) This is the secondary removal mechanism that will change some to normetanephrine and some to ne. Can also go from synaptic space to systemic circulation. Can also be oxidized by mao (monoamine oxidase: adrenergic receptors (adrenoceptors) - most organs have both receptors but have more of one than the other. Alpha adrenoceptors: responds to epinephrine more than ne.