PHYSICS 15A Final: PHYS15A Harvard 00 Fall Final
Document Summary
Directions: do not write in red ink. Nothing in red ink will be graded: write your name on every page of the exam, provide your answers in the designated space, the last page of the exam has a table of amino acids and co-factors. You may use the back of this page for scratch work but nothing written on this page will be graded: you have 10 total pages. Just draw out the reactive portions when required: molecular model kits and calculators are permitted, a significant fraction of your exams are photocopied before they are returned. An artificial enzyme called medhq synthase was engineered by creating multiple mutations in dhq synthase. Medhq synthase was shown to efficiently convert 3-deoxy- D-arabino-octulosonic acid 7-phosphate (daop) to methyldehydroquinate (medhq) through intermediate 1. Both (7r)- and (7s)-daop were found to be substrates for the enzyme. 1 (a) provide plausible mechanisms by which (7r)-daop and (7s)-daop are converted to intermediate 1.
