AS.020.305 Midterm: cell bio final study sheet (dragged) 13
Document Summary
When activated by the binding of fas ligand, the death domains on the cytosolic tails of the. Fas death receptors recruit intracellular adaptor proteins, which in turn recruit initiator procaspases (procaspase-8,procaspase-7},or both), forming a death-inducing signaling complex (disc). Once activated in the disc, the initiator caspases activate downstream executioner procaspases to induce apoptosis. When released into the cytosol, it has an entirely different function: it binds to a procaspase activating adaptor protein called apafl (apoptotic protease activating factor-l), causing the apafl to oligomerize into a wheel-like heptamer called an apoptosome. The apafl proteins in the apoptosome then recruit initiator procaspase proteins (procaspase-9), which are activated by proximity in the apoptosome, just as procaspase-8and -10 proteins are activated in the disc.
