Ch. 6 Notes (97% in the course

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Department
Biological Sciences
Course
BIOL 2051
Professor
All Professors
Semester
Winter

Description
Chapter 6 Virus Structure and Function General Properties of Viruses virionsObligate intracellular parasite made of nucleic acid surrounded by a protein coatViruses are very simpleOnly replicate inside hostNo nucleus organelles cytoplasmViral genomes containinformation for taking over host cell when a virus infects the host cell it turns the host cell in a virusmaking factoryinformation for making viral proteinsCapsid genome replication proteinsViroids and PrionsViroids RNA without capsid viruses without capsidsnaked virusesInfect plantsArent a huge amount of them knownMost studiedpotato spindle tuber viroidcircular ssRNAPrions Proteinonly infectious agentBSE mad cowcauses a spongy effect scrapie sheep CreutzfeldJakob kuru humanscaused by eating brains of a deceased person chronic wasting disease deer elkDefective protein causes normal protein to take on abnormal shape lose normal functionVirus StructureCapsidsAll viruses have a capsidCapsid protein coat surrounding nucleic acidCapsid proteins are arranged to give virion symmetry Isosahedral capsids poliovirus herpes virusRoughly spherical20 equilateral triangles or facesFilamentous capsids M13doesnt affect humans Eboladoes affect humansLong tube of protein with genome insideTube made up of 100s of identical protein subunits Tube length reflects size of viral genomeIf the viral genome is larger the tube will be longerIf the viral genome is smaller the tube will be shorterComplex capsids Mixture of icosahedralfilamentous shapesMany bacteriophage viruses that infect bacteriaAsymmetrical irregular shapesTend to be larger virusesPoxvirusesPicture Vaccinia cowpox virus TMV virions influenza virus attached to host cell HIV viruses TEM image of bacteriophage T4Virus StructureEnvelopesEnvelope lipid bilayer around capsid of some virusesAllows fusion to host cell membraneOnly occurs if host cell not covered by cell wallViruses that have envelopes are typically animal virusesBacteriophages are NONenvelopedEnvelope lipids come from hostas the virus is binding to the host cell it steals the envelope from the host cell the virus will then embed its own proteins in the envelope these proteins help the virus attach to other host cellsNot encoded by viral genome
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