Chapter 25 And 26 (Got A+ on the test)

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Louisiana State University
Biological Sciences
BIOL 2051

Chapter 25 Microbial PathogenesisHostPathogen InteractionsInfectionentry of pathogen or parasite Infection doesnt always cause diseaseMost infections removed by immune systemPrimary pathogensHave ability to penetrate host defensesOpportunistic pathogensCause disease only in compromised hostsImmune system defectiveBreak in tissue allows organism access to new siteLoss of other microflora allows organism to bloomPathogenicity of organismMeasure of ability to cause diseaseDetermined by genetic makeup of organismInfectious doseID50Number of organisms to colonize 50 of hostsVirulenceRate of lethal infections Lethal doseLD50Number of organisms to kill 50 of hosts Infection CycleSpread by direct contact shaking handsSpread by indirect contactContact with fomitesInanimate object or substance that can carry infectious microbesHorizontal transmission via vectorsMosquitoesyellow fever malariaReservoir for disease organism ex bird that is bitten by infected mosquitoMay not show disease symptomsMode of entry depends on pathogenMucosal surfaces wounds insect bitesVirulence FactorsVirulence genesEncode factors allowing pathogen to invade hostToxins attachment proteins capsulesPathogenicity islandsSection of genomeContain multiple virulence genesOften encode related functionsEg protein secretion system toxin productionTransferred as a block from other organisms very easilyVirulence FactorsStructurescharacteristics of pathogens that allow them to cause diseaseAdhesion ability to adhere to mucus membranes Virulence factors affecting adhesionCapsuleouter polysaccharide layer helps bacteria in attachment protects them from phagocytosis
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