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EXAM 2 GENETICS (97% in the course

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Department
Biological Sciences
Course Code
BIOL 2153
Professor
All

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BIOL2153DrSmithFall2011Chapter5Homeworkproblems23HemophiliacoAllaffectedindividualsaremaleoAllcarriersarefemaleoConditionisrecessiveoBasisforthisdiseasesexlinkedtraitattachedtotheXsexchromosomeoXlinkedtraitsFemalesarecarrierdiseasedgeneisonlyononeXBecausemenonlyhaveonechromosometheywillonlyhaveonealleleforthedisorderAoraWomenhavetwoallelesXchromosomesMucheasierformentohaveanXlinkedtraitthanafemalebecausemalesonlyhavetohaveoneXbutforfemalestohavethedisorderonemusthaveaaHemophiliaandColorblindoaCrosseshemophiliaAandcolorblindallmalesobCrosseshemophiliaBandnotallcolorblindallmalesoGeneticlinkagesomegenesassorttogethermoreoftenthannotNotcontrolledbythesamegenebutthegenesthatcontrolthetraitsarecloseinproximityonthechromosomeoAcrossovercanoccuroveranypartofhomologyseedrawingGenesaresoclosethattheytendtocrossoverAnycrossovereventwillcarrybothallelesoverunlessitoccursrightinthemiddleofthetwoallelesThisiswhysomegenesarelinkedtogetherandsomearenotoHowdoyoudeterminelinkagea100maleswhoarehemophiliaAarealsocolorblindDeterminelinkagechisquaretestChisquareTestQUESTIONONEXAM2oCoinflipFlipacoin10timesProbability5050Get6and4normalonlyonedeviation6040wouldbe10deviationGet9and1trickcoinoClickerdoyouthinkafaircoincouldyield60tailsand40headsin100cointossesNO22XOEEOobservedEexpected100events2classes22X6050501005022X405050100501005010050200504Degreesoffreedom211NullHypothesisRejectedlookatchartcoinisnotfairWhyiscalculatinglinkageusefuloItcantellyoutheorderofthegenesonthechromosomesgeneticmappingoCysticfibrosisgenehasbeenidentifiedbyusinggeneticlinkagetolinktophysicalspaceonachromosomeChiSquareProblemBIOL2153DrSmithFall2011Chapter6DNAPart1HomeworkProblems124711131518192227EXPERIMENTQUESTIONSONEXAMGeneticinformationcanmovefromdeadcellstolivingcellso1928FrederickGriffithexperimentswithsmoothSvirulentstrainStreptococcuspneumoniaeandroughRnonvirulentstrainoSmoothhaspolysaccharidelayerRoughlackspolysaccharidelayeroVirulentcancausediseasehaspolysaccharidelayerGoodforbacteriumbutbadforthehostPolysaccharidelayerphysicallyblocksaccesstothecellfromantibodiesimmuneresponseGriffithexperimentoFigureSmoothvirulentbacteriuminjectedintomousemousewilldieRoughbacteriuminjectedintomousemousewillliveHeatkilledcellularbacteriuminjectedintomousemousewillliveHeatkilledcellularbacteriumwithRbacteriuminjectedintomousemousewilldieLivingScellsfoundinliveroTransformationabilityofasubstancetochangethegeneticcharacteristicsofanorganismoSomethingfromheatkilledSbacteriatransformedthelivingRbacteriaintoSAregenescomposedofDNAorproteinoDNAOnlyfourdifferentsubunitsmakeupDNAChromosomescontainlessDNAthanproteinbyweightoProtein20differentsubunitsgreatervarietyofcombinationsChromosomescontainmoreproteinthanDNAbyweightAveryMacLeodMcCartyExperimentoMixedlivingRcellsandheatkilledScellsandovertimeyouwouldhavelivingScellsoTransformationwassuccessfulinvitrooButwhatwastheactiveprincipleTransformingprincipleDNAoTestedsampleforeveryknownmacromoleculeTreatedwithenzymesandthisshowedthatonlyDNAwasacandidatetoblocktransformationHersheyandChaseExperimento1952AlfredHersheyandMarthaChaseprovideconvincingevidencethatDNAisgeneticmaterialBlenderexperimentusingT2bacteriophageandbacteriaBacteriophagevirusneitherlivingordeadoBacteriophageliterallybacteriaeater3235RadioactivelabelsSforproteinPforDNAandBacteriophageT2lifecycle
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