GENE 540 Study Guide - Midterm Guide: Nocodazole, G1 Phase, Thymidine

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30 Jan 2019
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The value of being able to arrest in a particular phase helps us study what regulates the cell cycle. Study the starred ones: nocodazole: inhibitor of microtubule dynamics, thymidine: dntp synthesis inhibitors & Dna polymerase inhibitors, serum deprivation & contact inhibition arrests cells in g1. These can be used as anti-cancer drugs as well in order to arrest over-proliferating cells. Nocodazole leads to not being able to build the spindles so it stops at m-phase. Serum deprivation/contact inhibition stops at g1. Thymidine too much of this would inhibit thymidine kinase (this is required for synthesizing ntps), they will run out of dntps and the cycle will arrest in s phase. M-phase (the nuclear envelope would break down, chromatin would condense and the mitotic spindle gets built: there is some positive acting factor in m-phase that can drive any other cell into the. M phase cells have a factor that can promote m phase in.

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