GENE 540 Midterm: Anaphase Promoting Complex
Document Summary
Apc (multi-subunit complex) has 2 different subunits that are important; these are targeting subunits. One of them targets securin and the other one targets cyclin b to get out of m-phase. Apc is activated via phosphorylation; one of the subunits cdc20 targets securin for degradation so the cell can go from metaphase: another subunit, cdh1, targets. Cyclin b for degradation so the cell can leave the m-phase and go back to interphase: there are different cyclin-dependent kinases and cyclins that control different transitions. Point during the cell cycle when a cell becomes committed to divide, even in the absence of mitogens. Restriction point this is the point when cell becomes committed to divide, even in the absence of mitogens (mitogens are growth factors) You get the growth factors from serum. This is the point when the cell looks for growth factors.
