GENE 540 Midterm: Cell Cycle Proteolysis & Spindle Checkpoints

34 views2 pages
31 Jan 2019
School
Department
Course

Document Summary

The proteolysis at specific times is a major contributor to keep the cell cycle going to one direction. Proteolysis is pretty much irreversible: this helps the cell cycle to go in one direction. Scf with other targeting subunits are responsible for normal cyclin e cycling. D this would lead to the cell not passing through the restriction point. So if you made lots of p16 it would inhibit cdk4/cyclin. In this experiment they are expressing p16 when p16 is expressed, the cell gets arrested at. The mutant p16 cannot bind to the cdk, so you still get cells going from g1 to s phase. The graph on the right shows p16 being injected into fibroblast and then you see cells not going into. S-phase; however, if you inject p16 into a cell that has mutant rb-gene, then the cells will go into s-phase (hence, a bunch of p16 wouldn"t matter if you didn"t have rb)

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers

Related Documents