[BIOS 4630] - Final Exam Guide - Comprehensive Notes fot th..
[BIOS 4630] - Final Exam Guide - Comprehensive Notes fot the exam (32 pages long!)

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Ohio University
Biological Sciences
BIOS 4630
Crockett, Johnson

[BIOS 4630] Comprehensive Final Exam guide including any lecture notes, textbook notes and exam guides.find more resources at oneclass.com Lecture 1: BioChem Introduction 1/10/17 Notes I. Biological Chemistry (Biochemistry) a. Describes life in molecular terms b. Structure/function c. What are biomolecules made of? Ex. Proteins (amino acids and their composition) d. How are they organized? Assembled? Discrete units or protein complexes? e. How do their structures change? Under different physiological conditions (cell elevation or decrease in pH, or body temperature are examples) f. What are their functions? Why are they necessary? Consequences of non- function (e.g. disease)? Losing a protein function for example in cystic fibrosis. Mutations in the cystic fibrosis membrane receptor lead to loss in function of that protein g. Che▯i▯al r▯▯s ▯e▯essar▯ for life…. Pathwa▯ orga▯izatio▯/regulatio▯ II. Historical Perspective a. Wohler 1828: synthesized urea in lab, without requiring a kidney or an animal, either man or dog. i. This was really the origin of biochemistry ii. Biochemical pathway that leads to the synthesis of urea III. Biochemical Literature a. Journals devoted to all aspects of biochemistry, proteins, lipid structure etc. b. Allows us to understand biodiversity of biochemistry IV. Free Radical Biology and Medicine a. Reactive Oxygen Species (ROS): naturally produced in a variety of different metabolic reactions. Natural process. Some of these ROS are detrimental, some can do damage to cells or proteins or DNA or lipids. But there is a certain balance between beneficial ROS such as signaling and detrimental ROS leading to cell damage and cell death. b. CV, pulmonary, neurodegenerative diseases (atherosclerosis, Alzheimers): find more resources at oneclass.com
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