Conference Paper Annotated Bibliography.docx

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Department
Engineering
Course
ENGR 0012
Professor
Bursic
Semester
Summer

Description
2245 EXTRACELLULAR MATRIX: A POWDERED GROWTH STIMULATOR Oluyinka Olutoye, [email protected], 0012 Meyers 10:00 AM Katelynn Thomas, [email protected] ,0012 Meyers 4:00 PM Original Abstract Regenerative medicine, a medical practice focused on the regrowth of human tissue is not widely studied or practiced but is one of the most spectacular advancements in medical science [Steinhoff]. One cutting edge technique in the field is the use of extracellular matrices (ECM) to regenerate tissue, a process that has caused a major breakthrough with the possibility to change the whole world of medicine [Steinhoff]. Dr. Stephen Badylak of the McGowan Institute for Regenerative Medicine has created a method of producing an ECM powder that involves the extraction and decellularization (removal of cells) of a pig’s bladder so that only the ECM scaffold is left. The powder signals naturally present stem cells in a patient’s body to differentiate and multiply once applied to a wounded area [Rosenwald]. As a result of this breakthrough, victims of cuts and amputations now have the possibility of regenerating their own flesh rather than relying on prosthetics or having to live with burdensome injuries [Cohen]. The makeup of the ECM allows it to be a part of virtually every type of tissue healing process regardless of the degree of damage that has been done to the flesh. With such a wide variety of uses, the ECM has the potential to affect every human being. Not a lot is known about the use of ECM to regenerate tissue since it is a fairly new concept. Full limbs have still not been grown, but current research shows that the ECM has not yet reached its full potential [Rosenwald]. Scientists are working to find out why ECM functions the way it does and how they can manipulate it more toward the regrowth of full limbs. While addressing the ethical concerns and the overall importance of the extracellular matrix, this paper will examine the procedure of extracting and using the ECM powder to regenerate tissue, as it is a complicated and sophisticated procedure involving many steps and much vigilance. This will be done by highlighting the benefits of the ECM that make it better than other controversial prospective treatments and presenting information gathered from both research and a direct interview with Dr. Badylak. Bioengineering The use of extracellular matrix is a cutting edge topic in the regenerative medicine field. In regenerative medicine, tissue is regenerated by the use of strategies and procedures that would not have occurred in life’s natural cycle. This paper on extracellular matrices should be in the Bioengineering category of the 2012 Freshman Engineering Conference at the University of Pittsburgh, because extracellular matrices are naturally occurring in the human body but are also engineered to fit certain purposes in the bioengineering field. Revised Abstract Regenerative medicine, a medical practice focused on the regrowth of human tissue is not widely studied or practiced but is one of the most spectacular advancements in medical science [Steinhoff]. One cutting edge technique in the field is the use of extracellular matrices (ECM) to regenerate tissue, a process that has caused a major breakthrough with the possibility to change the whole world of medicine [Steinhoff]. Dr. Stephen Badylak of the McGowan Institute for Regenerative Medicine has created a method of producing an ECM powder that involves the extraction and decellularization (removal of cells) of a pig’s bladder so that only the ECM scaffold is left. The powder signals naturally present stem cells in a patient’s body to differentiate and multiply once applied to a wounded area [Rosenwald]. As a result of this breakthrough, victims of cuts and amputations now have the possibility of regenerating their own flesh rather than relying on prosthetics or having to live with burdensome injuries [Cohen]. The makeup of the ECM allows it to be a part of virtually every type of tissue healing process regardless of the degree of damage that has been done to the flesh. With such a wide variety of uses, the ECM has the potential to affect every human being. Not a lot is known about the use of ECM to regenerate tissue since it is a fairly new concept. Full limbs have still not been grown, but current research shows that the ECM has not yet reached its full potential [Rosenwald]. Scientists are working to find out why ECM functions the way it does and how they can manipulate it more toward the regrowth of full limbs. Throughout our paper, we will describe the work these scientists are doing and ECM’s potential by focusing on ways in which it has already been successful in regenerating sliced fingers and by explaining new approaches that are being taken to further its effectiveness. While also addressing ECM as an ethical alternative to other stem cell approaches, we will discuss the overall importance of the extracellular matrix. This paper will examine the procedure of extracting and using the ECM powder to regenerate tissue by highlighting ECM’s malleability and power that make it better than other controversial prospective treatments, detailing the many steps involved in obtaining ECM scaffolds and forming them into a powder, and presenting information gathered from both research and a direct interview with Dr. Badylak. Bioengineering The use of extracellular matrix is a cutting edge topic in the regenerative medicine field. In regenerative medicine, tissue is regenerated by the use of strategies and procedures that would not have occurred in life’s natural cycle. This paper on extracellular matrices should be in the Bioengineering category of the 2012 Freshman Engineering Conference at the University of Pittsburgh, because extracellular matrices are naturally occurring in the human body but are also engineered to fit certain pu
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