Conference Paper Annotated Outline.docx

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ENGR 0012

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Session C1 2245 EXTRACELLULAR MATRIX: A PROMISING BASIS OF TISSUE REGENERATION Oluyinka Olutoye ([email protected]), Katelynn Thomas ([email protected]) Abstrac— Regenerative medicine, a medical practice EXTRACELLULAR M ATRIX focused on the regrowth of human tissue, is not widely studied or practiced but is one of the most spectacular advancements in medical science [1]. One cutting edge We will begin this section by carefully describing the technique in the field is the use of extracellular matricesstances of which extracellular matrix is comprised of by referencing a book written by Robert P. Mecham named The (ECM) to regenerate tissue. ECM signals naturally presenExtracellular Matrix: An Overview. Once we completely stem cells in a patient’s body to differentiate and multdescribe it’s make up, we will describe its location around once applied to a wounded area [2]. The makeup of the ECM allows it to be a part of virtually every type of tissues and how the location benefits the cells while allowing them to perform their job of regeneration. We will describe healing and gives it the potential to affect every humanbroad aspects of extracellular matrix before we delve into being in the near future. the specifics of it, such as the proteins (glycoproteins, Not a lot is known about the use of ECM to regenerateproteoglycans and collagens) and other cellular features that affect it [4]. After describing the extracellular matrix as a tissue since it is a fairly new concept. Scientists are whole, we will introduce the process of extracting it and to find out why the ECM functions the way it does and hoindicate how its makeup allows it to be used as a structural they can manipulate it more toward the regrowth of full limbs. While addressing the ethical concerns and the overallfold for cellular regeneration to transition into the importance of the extracellular matrix, this paper will “Preparation and Use” subsection. examine the procedure of extracting and using the ECM Preparation and Use powder to regenerate tissue, as it is a complicated and sophisticated procedure involving many steps and much In this subsection, we will describe the decellularization of vigilance. This will be done by highlighting the benefits ofue and the process by which extracellular matrix is isolated and manipulated into a powder by highlighting the the ECM that make it better than other controversial prospective treatments and presenting information gatheredthods used in labs run by Dr. Badylak, a bioengineer at from both research and a direct interview with Dr. Badylak. University of Pittsburgh’s McGowan Institute for Regenerative Medicine. Referencing videos on extracellular matrices and Dr. Badylak himself, we will accurately Key Words—Amputees, Bioengineering, Extracellular describe the process and transition into how the extracellular Matrix, Regenerative Medicine, Scaffold matrices will call forth stem cells in the body, shifting the content to a more physical aspect before we explain R EGENERATIVE M EDICINE instances in which ECM has been used to regenerate fingers In this first section of our paper, we will begin broadly byhe following sections. describing the field of regenerative medicine, which is in the FINGER R EGENERATION category of bioengineering and the main topic of our paper, extracellularmatrices. We will explain regenerative The finger regeneration section will detail examples of the medicine as a relatively new field in which many new ECM’s success in humans. We will present the stories of a hobby shop owner and a California woman who both lost the scientists have been breaking boundaries and performing procedures that were not possible just a few years ago. tip of one of their fingers in accidents, demonstrating the We will then narrow down to the different types of potential power of the ECM. These stories cannot be used as regenerative engineering: Human Substances, Cells and complete scientific data because they did not occur in monitored studies, but they can be used as an indicator of Tissue, Embryonic Stem Cells, and Novel Materials [3]. After explaining these types of regenerative medicine, wehat scientific research in this field will do. Also, this will will emphasize the specific type of regenerative medicine wes our paper on the single topic of using the ECM for the will focus on, tissue engineering. Describing the tissueregrowth of fingers. The information in the previous sections provides a background for a better understanding of what engineering, we will introduce the use of the extracellular matrix to regenerate tissue and transition to the next section.d to the fingers of these two individuals. We will then transition into the topic of ethics by indicating that the ECM was the most ethical solution for both of these stories. University of Pittsburgh Swanson School of Engineering April 14, 2012 1 Oluyinka Olutoye Katelynn Thomas E THICS A DDITIONAL R EFERENCES [1] A. Bella. “Extracellular Matrix Could Lead to Advances in Regenerative The section on ethics will be used to present the use of extracellular matrices in tissue regeneration as an ethical Medicine.” (2011, December 20). Science Daily. [Online]. Available: alternative to other types of treatments. We will emphasize [2] E. Cohen. (2010, September 9). “Woman’s persistence pays off in that the ECM uses stem cells that are already in the patients’regenerative fingertip.” CNN Health. [Online Article]. Available: bodies rather than requiring the use of embryonic stem cells from other organisms. x.html?iref=allsearch. [3] H. Fernandes, L. Moroni, C. van Blitterswijk, and J. de Boer. (2009, Much controversy has surrounded the use of embryonic May 19). “Extracellular matrix and tissue engineering applications.” Journal stem cells so we will use this to our advantage when proving of Materials Chemistry. [Online]. Available: the ethical nature of the ECM. We will allude to the section titled “Extracellular Matrix” as we explain that the ECM [4] S. Badylak. (2007, May 8). “The extracellular matrix as a biologic scaffold material.” Elsevier. [Online.] Available: calls forth stem cells from the body of the patient. We will also reference the article titled “Recruitment of Progenitor &_user=10183724&_pii=S0142961207003456&_check=y&_coverDate=20 Cells by Extracellular Matrix Cryptic Peptide in a Mouse 07-09-01&view=c&wchp=dGLbVBA- zSkWA&md5=9ac047cf47b5c05df01db602fa90a0c7/1-s2.0- Model of Digit Amputation” to give further support to our S0142961207003456-main.pdf topic. This article does not explain the ethics of the ECM but[5] V. Agrawal, S. Tottey, S. Johnson, J. Freund, B. Siu, and S. Badylak. it does provide information that allows the reader to infer th(2011, October 17). “Recruit
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