BIOL 11100 Study Guide - Final Guide: Goitre, Adrenocorticotropic Hormone, Insulinoma

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Requirements: replication of genetic material, accurate segregation of genetic material, division of cytoplasm. Replication begins at origin of replication: terminus is bidirectional to origin of replication. Centromere: (visible constriction) holds sister chromatids together: consists of repeated short dna sequences. Kinetochore: proteins at centromere: attach to microtubules during mitosis. Telomeres: ends of chromosomes: replicated by: telomerase (protein) Chromosome compaction: chromosome must be folded in order to fit into cell. Replication and chromosome separation occur at different times. 5 parts: g1- first gap phase (pre-replication, s- dna synthesis (centrosome also duplicates, g2- second gap phase (post-replication, m- mitosis, cytokinesis- division of cytoplasm into two cells. Two irreversible steps: start: the commitment to divide, anaphase: the separation of chromosomes. Cell controls cycle with checkpoints: start/ restriction point, g2/m transition, anaphase. Cytokinesis: process of dividing one cell into two, divides cytoplasmic contents. Gene: segment of dna that codes for a trait. Genes coding for the same characteristics, same locations (loci)

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