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01:694:301 Study Guide - Midterm Guide: Pyrimidine Dimer, Pearson Education, 6-O-MethylguanineExam


Department
Molecular Biology and Biochemistry
Course Code
01:694:301
Professor
F Deis
Study Guide
Midterm

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Copyright © 2016 Pearson Education, Inc.
Biochemistry: Concepts and Connections (Appling et al.)
Chapter 23 DNA Repair, Recombination, and Rearrangement
1) O6-methylguanine has a high probability of base pairing with thymine to result in a post
replication mutation from a GC base pair to:
A) TA.
B) AT.
C) CG.
D) GT.
E) TC.
Answer: B
Objective: 23.1
Global LO: G2
2) The only function of Uracil-DNA N-glycosylase is to remove dUMP residues in DNA that
have been arisen by deamination of cytosine.
Answer: FALSE
Objective: 23.1
Global LO: G7
3) Which of the following types of DNA damage cannot be repaired by base excision repair?
A) Depurination
B) Cytosine deamination
C) Thymine dimer
D) Single-strand break
E) Base oxidation
Answer: C
Objective: 23.2
Global LO: G7
4) Nucleotide excision repair:
A) involves a multisubunit enzyme.
B) preferentially repairs genes that are being actively transcribed.
C) involves making nicks on either side of a DNA lesion.
D) uses helicase, polymerase and ligase to repair the DNA.
E) all of the above.
Answer: E
Objective: 23.2
Global LO: G7
5) Photoreactivation using DNA photolyase is responsible for direct repair of thymine dimers in
all organisms.
Answer: FALSE
Objective: 23.2
Global LO: G7
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